AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok.

The Genomics Research Center within the Quantitative Medicine and Genomics organization at AbbVie is seeking a talented and motivated Senior Scientist to join the Human Genetics team to support our target discovery and development efforts. This individual will contribute to studies aimed at novel target discovery and understanding the biological mechanisms of diseases of interest to AbbVie. The ideal candidate will be detail-oriented and collaborate with cross-functional teams to design, interpret, and deliver genomic analyses that inform our pipeline. This position is in North Chicago, IL with no remote option.

Key Responsibilities

• Lead genetics-driven target and biomarker identification across AbbVies therapeutic areas using cutting-edge methods and large-scale biobank datasets (e.g., FinnGen, Alliance for Genomic Discovery, UK Biobank, All of Us) and clinical cohort data.
• Design and execute innovative approaches to uncover genotype-phenotype associations through disease-focused case-control and time-to-event study designs.
• Identify genetic determinants influencing disease progression and patient response to treatments.
• Analyze polygenic risk scores (PRS) to enhance patient stratification, identify genetically defined subgroups, gain insights into disease mechanisms, and support precision medicine strategies.
• Assess heterogeneity in disease risk and investigate how PRS profiles are associated with differences in treatment responses.
• Systematically mine internal and external phenome-wide association study (PheWAS) datasets to identify novel and population-specific genetic associations.
• Analyze genomics data from clinical trial participants to identify response biomarkers and support reverse translation efforts.
• Perform and interpret post-GWAS analyses (e.g., fine mapping of GWAS loci, GWAS signal colocalization with molecular QTLs, Mendelian Randomization and others) to identify and prioritize causal genes and targets.
• Integrate single-cell omics and proteomics datasets with genomic and clinical data.
• Collaborate with therapeutic area scientists to generate therapeutic hypotheses, support novel target identification and validation through exploratory analyses, and facilitate progression through pipeline phase transitions.
• Lead cross-functional projects with therapeutic area leads.

Required Qualifications

• Bachelors Degree or equivalent education and typically, 10-12 years of experience, Masters Degree or equivalent education and typically 8-10 years of experience, PhD and 0-4 years of experience.
• Fluency in programming languages such as R and Python and working in command-line on HPC clusters.
• Expertise in biobank scale genome-wide association studies (GWAS) and rare variant association studies (RVAS).
• Hands-on experience in methods and tools such as PLINK, SAIGE, REGENIE, fastGWA, SKAT/ACAT.
• Hands-on experience working with different types of genotype data such as array, WGS, and imputed.
• Hands-on experience with electronic health records (EHR) and OMOP CDM format data.
• Familiarity with open-source genomics and omics resources (e.g., Open Targets, HGMD, GTEx, eQTL Catalog and others).

Preferred Qualifications

• Previous industry experience in pharmaceutical or biotechnology companies working with large-scale human genetic datasets.
• Experience in cloud genomics research environments (e.g., All of Us Researcher Workbench, UK Biobank Research Analysis Platform and FinnGen sandbox).
• Strong track record of relevant scientific publications and presentations.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible toparticipatein our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's soleandabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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