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Job Description
Director II, LNP Platform Technology
Company Description
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.
Job Description
Job Description:
We are seeking a highly motivated and collaborative technical leader responsible for innovation and development of our LNP platform technology. The successful candidate will work within a cross-functional teams to design and develop LNPs/tLNP platform technology in support of our pipeline. The candidate is responsible for establishing and leading LNP innovation strategy with respect to lipid design, chemistry, formulations and targeted non-viral delivery systems with line of sight to future products and pipeline growth
Responsibilities and Duties:
Serves as a scientific and technical leader in the organization with special emphasis on lipid nanoparticle (LNP)-based drug delivery systems for nucleic acids.
Lead the strategy to innovate, develop, and optimize the targeted LNP platform to support programs across therapeutic areas
Have a deep understanding of lipid and LNP design principles, stability, scale-up and scale out processes and their impact on critical product attributes. Ensure successful scale up of drug product formulation production and purification unit operations from bench scale to larger scale in support of a development candidate.
Prepare LNP-related project plans, timelines, budget projections, and ensure development activities proceed in alignment with key stakeholders in alignment with organizational goals and budget
Lead analysis and summarization of complex data sets, and communicate clearly at internal program meetings, cross-functional reviews and governance forums.
Collaborate with various discovery and development groups across the organization including mRNA, antibody, analytical and process development groups to advance pipeline programs
Lead authoring, review and approval of technical reports relevant to the function
Manage and mentor a team of >10 scientists and associates at AbbVie sites located on the east and west coasts
Qualifications
PhD. in Chemistry, Biochemistry, Chemical or Bioengineering
12+ years (PhD) of experience in pharmaceutical or biotechnology industry
Strong experience and technical mastery in LNP design & development including analytical characterization and CMC regulatory knowledge
Demonstrated expertise in developing liquid, frozen and lyophilized formulations of lipid-based nucleic acid formulations through clinical development
Prior experience leading and mentoring a team of >10 scientists/associates
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:
The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this postingbased on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore orless than the posted range. This range may bemodifiedin thefuture.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
This job is eligible toparticipatein our short-term incentiveprograms.
Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission,incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless and until paidandmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
